Anesthetics and Platelet Inhibition as Measured by PAA

Analytical Control Systems, Inc

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SPAT™/ PAA™ and the Detection of Platelet Inhibition from Anesthetics

Anesthetics and Platelet Inhibition as Measured by SPAT/PAA

A study performed at Analytical Control Systems, Inc. (Feb. 2000) by Pauline Bonderman to determine if platelet inhibition is caused by five different anesthetics.

Platelet function is inhibited by many common pain killers. This study was to determine if platelet inhibition is created by the use of five different anesthetics. Anesthetics were mixed with a patient’s normal plasma and the level of platelet inhibition was noted with SPAT™ (PAA™).

Anesthetic	Mixing Concentration
	1:50	1:100	1:1000
Isoflurane	50 seconds	44 seconds	25 seconds
Xylazine	300 seconds	114 seconds	33 seconds
Pentobarb	50 seconds	53 seconds	25 seconds
Telozal	65 seconds	47 seconds	28 seconds
Buprenex	35 seconds	30 seconds	30 seconds
Telozal & Xylazine	Inhibited	Inhibited	Inhibited

Normal value for this patient (n = 4) was 41 seconds with a range of 38-42 seconds. This study suggests that anesthetics commonly produce some inhibition of the PAA platelet function. The greatest level of inhibition was seen with a combination of Telozal and Xylazine which totally inhibited PAA platelet aggregation. Highly prolonged results for this patient were obtained with the use of Xylazine but effects were noted with all but Buprenex.

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